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Journal: Journal of the Endocrine Society
Article Title: Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure
doi: 10.1210/jendso/bvaa042
Figure Lengend Snippet: Correlations between lower body fat mass and lipid parameters and frequently sampled intravenous glucose tolerance test (FSIVGTT data). A, Eleven apple- and 10 pear-shaped women were enrolled in the clinical trial. Correlations were established between the percentage of fat mass in the legs relative to total fat mass and circulating triglycerides levels, cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/HDL, percentage of liver fat determined by magnetic resonance spectroscopy, and visceral adipose tissue (VAT) mass estimated by dual‐energy X‐ray absorptiometry. B, FSIVGTT was performed and completed by 18 women in the initial group. The design of the test and the blood collection times are summarized at the arrows. The results of the minimal model method of Bergman are summarized in the tables under the graph. C-E, Respiratory quotient (RQ), glucose, and free fatty acid (FFA) levels during the FSIVGTT. C, RQ data were individually reported for each group and each time interval. * P less than .05 Wilcoxon test, RQ value compared to baseline value. D, Glucose concentrations for 5 hours after administration of glucose at time 0 and insulin at 20 minutes. For each time point, average data ± SD in each group were reported and plotted (red for apple and blue for pear). E, FFA concentrations (top graph) and percentage decrease of FFA (compared to baseline concentration—bottom graph) are represented. * P less than .05 repeated analysis of covariance (baseline as covariate).
Article Snippet: We used a repeated-measures analysis of covariance with basal
Techniques: Spectroscopy, Concentration Assay